Mouse Specifics, Inc. is pleased to be a sponsor of the Young Life Scientists’ Symposium 2014: Current Progress on the Physiology & Pharmacology of TRP Channels, to be held October 4 in the Franklin Wilkins Building at King’s College London, in the heart of London.


The YLS Symposium will feature eight speakers ranging from senior established researchers to industry specialists who have prepared lectures concerning their respective studies on the TRP channels. The symposium will begin in the early morning at 8:30 am and continue through the day, concluding with dinner.  The day is filled with different events from workshops, to lectures, and poster viewings. The symposium is aimed at young life scientists and early career researchers, and will host more than 100 delegates within its beautiful venue overlooking the city.



The TRP (Transient Receptor Potential) superfamily of cation channels plays a critical role in sensory physiology and functions as signal integrators when activated by different stimuli. There are distinct therapeutic opportunities for drugs targeting TRP channels in various diseases. This symposium will provide an up-to-date review on the subject, featuring world-leading experts and young scientists discussing their latest research in TRP channels. One of the speakers, a luminary in the fields of cardiovascular disease, inflammation, and pain is Dr. Susan Brain. Her research includes the role of the TRP channels (TRPA1,TRPV1, TRPC5), and related peptides on peripheral blood flow, blood pressure and inflammation, of relevance to cardiovascular diseases (hypertension), inflammation & pain (arthritis), sepsis and aging.

Another speaker, Dr. Scott Early studies the importance of TRP channels (TRPA1, TRPM4, TRPV3, TRPV4) in understanding blood flow regulation and influencing the function of smooth muscle cells, endothelial cells and astrocytes in cardiovascular physiology in order to develop new therapies to treat cardiovascular-related diseases. By clicking here you can find small excerpts about the other lectures taking place at the symposium.

Mouse Specifics, Inc. is pleased to exhibit its in vivo instrumentation at the venue because of its utility in describing early evidence of cardiac disease and pain in animal models of various disorders in which TRP channels have been shown to play a role.  Dr. Thomas Hampton, CSO of MSI, will be traveling to London, to showcase the DigiGait and ECGenie for their application in TRP research.


YLS3The ECGenie, for example, readily describes cardiac hypertrophy, and also sympathetic up-regulation associated with sympathetic pain.  At ~1/10th the cost of radiotelemetry, the ECGenie reports all of the same measures, including the PQRST interval durations , and heart rate variability, in the time and frequency domain.  Yet the ECGenie does not require anesthetic, surgery, or restraint.  Rather, the signals are detected passively in awake animals as young a 1-day old.  The elegant technology of the ECGenie gives the researchers the opportunity to compile dependable cardiac data from a large amount of subjects in a short amount of time. To learn more about the ECGenie click here.


DigiGait was designed and developed to provide the best possible instrumentation to study coordinated gait in animal models of pain, trauma, arthritis, and CNS disorders.  Voluntary and treadmill walking, DigiGait performs gait analysis of mice and rats over a range of walking and running speeds.  Ventral Plane Imaging (VPI) Technology continuously images the underside of the animals walking atop of the patented motorized transparent treadmill belt, generating “digital paw prints” and dynamic gait signals.  These dynamic gait signals, generated for each of the 4 limbs, describes the posture and kinematics of the animal that reflect strength, balance, and coordination. Animals can also be challenged to walk up an incline or down a decline to maximize the details about the subjects’ motor abilities. To learn more about DigiGait can also be found here.