Non-invasive Heart Monitoring of Newborn Rodents
There is a growing awareness that the cardiovascular system is implicated in a wide range of inflammatory and neurological conditions. Many fragile genetically modified mice die at a very young age inexplicably.
LifeSpoon
™ provides researchers the opportunity to non-invasively monitor the electrocardiogram in newborn laboratory animals from day 1 of life. The design of the LifeSpoon includes a heated array of conductive electrodes in a warm cozy “spoon”, thereby minimizing handling of the pups. Applications include arrhythmia detection, health monitoring, and drug screening in fragile neonates and very young transgenic and knockout animals.
LifeSpoon features: |
EzCG Analyses software features: |
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Publications and Applications:
- Ahmed SS, et al. rAAV gene therapy in a Canavan’s disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system. Mol Ther. 2016 Apr 4. Request Article
- Heier CR, DiDonato CJ. ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy. Front Biosci (Elite Ed). 2015 Jan 1;7:122-33. Read Article
- Heier CR, Hampton TG, Wang D, Didonato CJ.
Development of electrocardiogram intervals during growth of FVB/N neonate mice. BMC Physiol. 2010 Aug 24;10:16. Read Article