Non-invasive Heart Monitoring of Newborn Rodents10

 

There is a growing awareness that the cardiovascular system is implicated in a wide range of inflammatory and neurological conditions. Many fragile genetically modified mice die at a very young age inexplicably.

LifeSpoon

™ provides researchers the opportunity to non-invasively monitor the electrocardiogram in newborn laboratory animals from day 1 of life. The design of the LifeSpoon includes a heated array of conductive electrodes in a warm cozy “spoon”, thereby minimizing handling of the pups. Applications include arrhythmia detection, health monitoring, and drug screening in fragile neonates and very young transgenic and knockout animals.

LifeSpoon features:

EzCG Analyses software features:
  • “Quick-connect” to the ECGenie
  • Reusable/disposable footpad electrodes
  • Heating of spoon via USB connection
  • “Spoon” subject back to nest after ECG recording
  • Analysis of ECG from newborn rodents
  • HRV algorithms specific to the developing conduction system
  • Time domain tachogram and frequency domain power spectra
  • Learn more about EzCG

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Publications and Applications:

  1. Ahmed SS, et al.  rAAV gene therapy in a Canavan’s disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system. Mol Ther. 2016 Apr 4.  Request Article
  2. Heier CR, DiDonato CJ. ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy. Front Biosci (Elite Ed). 2015 Jan 1;7:122-33. Read Article
  3. Heier CR, Hampton TG, Wang D, Didonato CJ.
    Development of electrocardiogram intervals during growth of FVB/N neonate mice. BMC Physiol. 2010 Aug 24;10:16. Read Article