Presented at the American Heart Association was a study that compared ECG data recorded via the ECGenie “through the paws” technology to that obtained via telemetry. The data were the same. Both approaches record the equivalent of an Einthoven limb-lead. Whereas the telemetry requires the animals undergo surgery and recovery for implantation of the transmitters, the ECGenie enables recording from awake mice immediately, from day 1 of life.
Not often. Sometimes during a demonstration or class, where there are many onlookers and a noisy environment. But it is not usual in a quiet room with a single operator managing the recording of the ECG signals to have any mice jump off of the ECGenie.
3. How is the ECG signal quality?All of the ECG signal morphology can be identified and all of the PQRST interval durations determined. Physiological signals can be confounded by extraneous noise, and the ECGenie includes noise-reducing technology to maximize the signal and minimize the noise. The software includes the generation of the ensemble averaged signal that depicts the ECG morphology, from which it is clear that the P Q R S and T are identifiable…non-invasively…via the subject’s paws.
4. Are there any size limitations with the ECGenie?
The ECGenie can record the electrocardiogram in newborn mice and rats from day 1 of life through old age, including rats sized ~600 grams.