ECGenie Publications

The following is a partial listing of publications incorporating Mouse Specifics instrumentation.  Some of these you can grab, others you might need to ask us for because of copyright laws.  Enjoy!




Ahmed SS, et al.  rAAV gene therapy in a Canavan’s disease mouse model reveals immune impairments and an extended pathology beyond the central nervous system. Mol Ther. 2016 Apr 4 Read Abstract


Heuermann RJ, et al. Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Neurobiol Dis. 2016 Jan;85:81-92. doi:10.1016/j.nbd.2015.10.005. Read Abstract


Refinetti R. Cicardian Physiology.  3rd Edition  Boca Raton, FL: CRC Press. ISBN 9781466514980 – CAT# KE16659.


Kosaraju K, et al.   Non-invasive evaluation of cardiac repolarization in mice exposed to single-wall carbon nanotubes and ceria nanoparticles via intratracheal instillation. Environ. Sci.: Nano. 2016 Advance Article DOI: 10.1039/C5EN00225G Read Abstract


Wang T, et al. Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function. Mol Cell Biol. 2016 35:1281–1298. doi:10.1128/MCB.01156-14. Read Abstract




Heier CR, DiDonato CJ.  ECG in neonate mice with spinal muscular atrophy allows assessment of drug efficacy. Front Biosci (Elite Ed). 2015 Jan 1;7:122-33. Read Abstract


Hoover DB, et al. Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis. Shock. 2015 Feb;43(2):185-91. doi: 10.1097/SHK.0000000000000272 Read Abstract


Lowe J, et al.  The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases. 2015 2:257–268. DOI 10.3233/JND-150099 Read Abstract




Cook JR, et al. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.  J Clin Invest.  2014 124(3):1329–1339. doi:10.1172/JCI71059. Read Abstract


D’Souza A, et al. Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nature Communications. 2014 May13;5:3775. doi: 10.1038/ncomms4775 Read Abstract


Dweck D, et al.  Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy. The Journal of Biological Chemistry.  2014 August 15; 289(33):23097–23111. Read Abstract


Jaber SM,  et al. Dose Regimens, Variability, and Complications Associated with Using Repeat-Bolus Dosing to Extend a Surgical Plane of Anesthesia in Laboratory Mice.  J Am Assoc Lab Anim Sci. 2014 Nov; 53(6): 684–691. Read Abstract


Kay J, et al. Electrocardiographic markers for cardiac hypertrophy in mice bred for high voluntary wheel running. The FASEB Journal. 2014 April, vol. 28 no.1 Supplement 881.11 Read Abstract


Mielcarek M, et al., Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington’s Disease. PLoS Genetics.  2014 August 7 Open Access: Read Abstract


Moreth K, et al. High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains. J Comp Physiol B. 2014 184(6):763-75.  Read Abstract


Morgan JL, et al. Effects of housing density in five inbred strains of mice. PLoS One. 2014 Mar 21;9(3):e90012. Read Abstract


Mielcarek M, et al. The Huntington’s Disease-Related Cardiomyopathy Prevents a Hypertrophic Response in the R6/2 Mouse Model. PLoS One. 2014 Sep 30;9(9):e108961. doi: 10.1371/journal.pone.0108961. Read Abstract


Westlund KN, et al. A rat knockout model implicates TRPC4 in visceral pain sensation. Neuroscience. 2014 March 14; 262: 165–175. doi:10.1016/j.neuroscience.2013.12.043.NIH Read Abstract



Duerschmied D, et al.  Plateletserotoninpromotestherecruitmentofneutrophilstositesofacute inflammationinmice. Blood. 2013 121(6):1008-1015. Read Abstract


Neary MT, et al. A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech. 2013 Mar; 6(2): 503–507. doi: 10.1242/dmm.010587. PMCID: PMC3597031. Read Abstract


Sugihara M, et al. Usefulness of Running Wheel for Detection of Congestive Heart Failure in Dilated Cardiomyopathy Mouse Model.  2013 January Volume 8 (1): 1-11. doi:10.1371/journal.pone.0055514 Read Abstract




Hampton TG, et al. Developmental changes in the ECG of a hamster model of muscular dystrophy and heart failure. Front. Pharmacol. 2012 18 May Read Abstract


Paigen B, et al. Physiological effects of housing density on C57BL/6J mice over a 9-month period J Anim Sci 2012 December; 90(13): 5182–5192. doi:10.2527/jas.2012-5417. Read Abstract




Heier CR, et al. Development of electrocardiogram intervals during growth of FVB/N neonate mice.  BMC Physiol. 2010 Aug 24;10:16. Read Abstract


Heier CR, et al. Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice.  Hum Mol Genet. 2010 Aug 18. [Epub ahead of print]. Read Abstract




Non-invasively record ECGs in mice.
Arizona Branch AALAS Newsletter Vol. 22 No. 1 February 2009 p.13.


Isenberg JS, et al. Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to
vasoactive stress. Matrix Biol. 2009;28:110-9. Read Abstract


Shuqin Xing, et al. Genetic influence on electrocardiogram time intervals and
heart rate in aging mice. Am J Physiol Heart Circ Physiol. 2009; 296:H1907-13. Read Abstract


Mabe AM and Hoover DB
Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice
Cardiovascular Research 2009; 82:93–99. Read Abstract


Lachance D, Plante E, Bouchard-Thomassin A, Champetier S, Roussel E, Drolet MC, Couet J
and Arsenault M. Moderate Exercise Training Improves Survival and Ventricular Remodeling in
an Animal Model of Left Ventricular Volume Overload. Circ Heart Fail. 2009; 5:437-45. Read Abstract


Lynch KR, Macdonald TL
RECEPTOR AGONISTS United States Patent Application 20090105315. Read Abstract




Cho H, Park C. ,Hwang I, Han S, Schimel D, Despres D. and Kehrl JH Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus. Molecular and Cellular Biology 2008, 28:2590–2597. Read Abstract


USES THEREOF United States Patent Application 20080302675.




Lewis W, Miller Y, Haase C, Ludaway T, McNaught J, Russ R,
Steltzer J, Folpe A, Long R and Oshinski J – HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure Lab Invest 2005; 85:182-92.


Lewis W, Haase CP, Miller YK, Ferguson B, Stuart T, Ludaway T, McNaught J, Russ R, Steltzer J., Santoianni R, Long R, Fiermonte G, Palmieri F. Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. Lab Invest. 2005;
85:972-81. Read Abstract


Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M. Diet-induced-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 2005 111:3457-64.




Amende I, Dubach JM, Piskorski K, Morgan JP, and Hampton TG. ECG Monitoring and Analyses in Mice. The Physiological Genomics of the Critically Ill Mouse in Basic Science for the
2004 pgs. 89-100.


Bachman E., Hampton TG, Dhillon H, Amende I,
Wang J., Morgan JP and Hollenberg AN – The Metabolic and Cardiovascular Effects of Hyperthyroidism are Largely Independent of Beta-Adrenergic Stimulation Endocrinology 2004;145:2767-74.


Maddatu TP, Garvey SM, Schroeder DG, Hampton TG, Cox GA. Transgenic rescue of neurogenic atrophy in the nmd mouse reveals a role for Ighmbp2 in dilated cardiomyopathy. Hum Mol Genet. 2004;13:1105-15.


Piskorksi K, Kale A, Chu V, Otero JM, Gladstone K, Mueller P, Amende I, and Hampton TG. Non-invasive physiology in conscious mice. 2002 Fourth World Congress Alternatives Congress
Trust Proceedings. 2004, in press. ATLA 32, Supplement 1, 195–201, 2004. Read Abstract


Sanna MG, Liao J, Jo E, Alfonso C, Ahn M, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H; Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively,
Regulate Lymphocyte Recirculation and Heart Rate. The Journal of Biological Chemistry 2004; 279: 13839–13848. Read Abstract


Schuldt AJT, Hampton TG, Chu V, Vogler CA, Galvin N, Lessard ML, Barker JE. Cardiac anomalies in beta-glucuronidase (GUSB) null mice are corrected by non-ablative neonatal
marrow transplantation. Proc Nat Acad Sci 2004; 101:603–608.


Sergey V. Ivanov, Jerrold M. Ward, Lino Tessarollo, Dorothea McAreavey, Vandana Sachdev,_ Lameh Fananapazir,_ Melissa K. Banks, Nicole Morris, Draginja Djurickovic, Deborah E. Devor-
Henneman, Ming-Hui Wei, Gregory W. Alvord, Boning Gao, James A. Richardson, John D. Minna, Michael A. Rogawski, and Michael I. Lerman† – Cerebellar Ataxia, Seizures, Premature Death, and Cardiac Abnormalities in Mice with Targeted Disruption of the Cacna2d2 Gene American Journal of Pathology 2004; 165:1007-1018. Read Abstract




Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, Andrews NC, Simons M, Krieger M. Probucol prevents early coronary heart
disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein-E double knockout mouse. Proc Nat Acad Sci 2003; 100:7283-7288. Read Abstract


Sutliff RL, Haase C, Russ R, Hoit BD, Morris R, Norman AB, and Lewis W. Cocaine Increases Mortality and Cardiac Mass in a Murine Transgenic Model of Acquired Immune Deficiency
Lab Invest ; 2003; 83: 983. Read Abstract


Svenson KL, Bogue MA, Peters LL. Invited review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. J
Appl Physiol 2003 94:1650-9. Read Abstract




Braun A, Trigatti BL, Post MJ, Sato K, Simons M, Edelberg JM, Rosenberg RD, Schrenzel M, Krieger M. Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic
Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E. Deficient Mice. Circ Res 2002; 90: 270-276. Read Abstract


Chu V, Otero JM, Lopez O, Sullivan M, Morgan JP, Amende I, Hampton TG. Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular dystrophy. Muscle & Nerve 2002;513-519. Read Abstract


Min JY, Sullivan MF, Yan X, Feng X, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG. Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial
Am J Physiol Heart Circ Physiol 2002 Dec;283(6):H2466-71. Read Abstract




Chu V, Otero JM, Lopez O, Morgan JP, Amende I, Hampton TG. Method for non-invasively recording electrocardiograms in conscious mice. BioMedCentral Physiology 2001, 1(1):6. Read Abstract




Amende I, Chu V, Morgan JP, and Hampton TG. Angiotensin II AT1 receptor blockade attenuates isoproterenol-induced cardiac hypertrophy in mice. Eur Heart J, 27(Supp.):2161. 2000.




Shioi T, Hampton TG, Douglas P, and Izumo S. Dominant negative p21ras causes a progressive dilated cardiomyopathy in transgenic mice. Circulation, 1999; 100(18);I-52.