Neuroscience Blog Posts 10-7

10. AlphaB-crystallin mediates peripheral nerve regeneration
AlphaB-crystallin (αBC) is a heat shock protein that is highly expressed in many neurological disorders, including Parkinson’s disease and amyotrophic lateral sclerosis.   There is great interest in developing αBC as a therapy for many types of nerve injury. Optic neuropathy, for example, has been rescued with exogenous αBC via decreases in microglial activation and promotion of nerve oligodendrocyte survival. Lim and colleagues from Calgary investigated whether αBC could influence regeneration and functional recovery following peripheral nerve injury in mice.

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Neuroscience Blog Posts 6-4

6. Neuromusculoskeletal modelling and the gain transition of a quadruped according to its speed in rats  

This poster details a neuromusculoskeletal model of rat hind limbs during walking and trotting. Toeda and colleaguesneuroscienceAbstract6 from Tokyo developed a musculoskeletal model of the fore- and hind limbs of the rat based on empirical anatomical data. To model the muscles, they focused on six prime muscle for the forelimbs, and seven muscles for hind limbs. respectively.

They present a neural system model invoking limb movement control, according to muscle synergy to account for coordinated structure in muscle activities, and postural feedback control, based on shoulder height, hip height and horizontal center of mass velocity. They present simulations of walking and trotting gait, and impose defects of the postural feedback system (by lesions to the cerebellum) to induce unstable gaits and tripping.
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Neuroscience Blog Posts 3-1

3. Because we’re all about that mouse, ‘bout that mouse, and gerbil…..

 

There is a growing awareness of the link between compromised heart function and nervous system abnormalities. Abstract3.1This point is beautifully conveyed in a poster presented by Dr. Anand Pandey and colleagues this coming Sunday at SfN. We are particularly excited to see how treadmill locomotion in rats is affected after cardiac arrest.

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