ECGenie vs. Telemetry

The heart is a powerful organ, sending blood through thousands of miles of vessels to fuel the body.  This intricate system works continuously, rhythmically ~100,000 times per day, to provide us humans with oxygen and nutrients while cleansing our systems of harmful waste.   Each cycle is activated by an electrical impulse. Read More

The ECGenie for Safety Pharmacology

ICH S7A and S7B guidelines recommend the use of conscious animals for assessment of non-clinical cardiovascular safety of new chemical entities prior to testing in humans. There is growing interest in non-invasive ECG recording in rodents to enable an early cardiac assessment thereby possibly reducing later stage development attrition (1 ).   Read More

Mice with Experimental Cerebral Malaria: the ECG in Conscious Mice and Potential Therapies

Human cerebral malaria (HCM), a complication of plasmodium falciparum infections, is the cause of over 1 million deaths worldwide each year, more deaths than any other parasitic disease.   It is important to understand how to best treat HCM. There are many reports of conduction system disturbances in humans with malaria. Little is known, however, about the electrocardiographic (ECG) features of mice with experimental malaria. Read More

Straight from the Heart? Congenital neuromuscular disorders revealed by electrocardiographic recordings in newborn mice and hamster pups

Aberrant autonomic signaling is being increasingly recognized as an important symptom in neuromuscular disorders. The δ-sarcoglycan-deficient BIO TO-2 hamster is recognized as a good model for studying mechanistic pathways and sequelae in muscular dystrophy and heart failure, including autonomic nervous system (ANS) dysfunction. Read More