The Young People’s Project: Math Literacy and Social Change

Mouse Specifics, Inc. is proud to provide a workshop entitled “Of Mice and Men: Translation
of Animal Studies to the Human Condition” at the Young People’s Project “Teen STEAM
Day”, Thursday July 24 at the Museum of Fine Arts in Boston.
What is a S.T.E.A.M. Day? Science, Technology, Engineering, Art, and Mathematics coming
together for an afternoon of fun and educational workshops lead by professionals and artists for
local Cambridge and Boston high school students with real world experience of S.T.E.A.M. Read More

A Mouse Walks into a Bar….

Coordinated ambulation is fundamental to our ability work and play.  As bipedals, we humans invoke our upper limbs in walking to a greater extent than we conscientiously appreciate.  Coordinated movement requires sensory and proprioceptive inputs to rapidly formulate and execute the concerted motor response; loss of even a portion of an arm greatly affects lower limb posture and kinematics.   Read More

Gait Abnormalities and Progressive Myelin Degeneration

Leukodystrophies are a heterogeneous group of rare, usually genetic, disorders primarily affecting myelin. Named disorders include Pelizaeus-Merzbacher disease, Krabbe disease, and Canavan disease. Mouse models of such rare disorders are important to their understanding and treatment because of the availability of tools and techniques for teasing out the genetic causes and effects in mice. Gait disturbances are common to the leukodystrophies, and quantifying gait in animal models can aid in determining the efficacy of potential therapies. Read More

The ECGenie for Safety Pharmacology

ICH S7A and S7B guidelines recommend the use of conscious animals for assessment of non-clinical cardiovascular safety of new chemical entities prior to testing in humans. There is growing interest in non-invasive ECG recording in rodents to enable an early cardiac assessment thereby possibly reducing later stage development attrition (1 ).   Read More

Treadmill vs. Overground Locomotion for Accurate Gait Analysis

For countless individuals who enjoy walking and running, nothing beats a walk through the woods, a run along the beach, or laps around a track. The conveniences of a stationary treadmill to satisfy the desire for exercise or maintain health cannot be disputed. Treadmills are used routinely by millions of individuals as an alternative to walking and running overground. Treadmills, moreover, are used regularly as diagnostic tools for cardiovascular diseases and movement disorders. Read More