Sylvester Stallone, the creative genius behind the universally known and beloved boxer Rocky Balboa, was recently honored with the Golden Globe for the best supporting actor in his seventh “Rocky” film Creed. Mr. Stallone may yet again be awarded an Academy Award [Rocky won Best Picture in 1977], in now-realized recognition of his talents as an actor.
This CNN headline was too good to pass up! : Mouse Spotted on Mars?
Given that Mouse Specifics, Inc. is now internationally recognized as a leader in novel in vivo life sciences instrumentation, is it possible that perhaps our innovative technology is making its way throughout the solar system? Is that the ECGenie set up in the HAB in The Martian, director Ridley Scott’s film adaptation of the best selling book by Andy Weir?
|Thursday, October 1st @ 11:00 AM EDT (GMT -4) An essential webinar for scientists interested in methodology, best-practices and techniques for identifying early and subtle quantitative physiological markers of strength, balance and coordination in animal models of pain, CNS, neuromuscular and neurodegenerative disorders.|
|In this exclusive event sponsored by Mouse Specifics, Inc., Dr. Thomas Hampton will provide an overview of essential parameters for studying gait in laboratory rodents. Topics will include key aspects of coordinated movement [walking] such as stride, swing, stance and ataxia. He will discuss how animals execute “stepping” via the convergence of motor and sensory inputs and will present a myriad of conditions that can affect walking along with how these conditions can be quantified for use as physiological markers of movement disorders. Dr. Charles Meshul, Research Biologist and Professor at Veterans Hospital, Portland and Oregon Health & Sciences University, will present gait data obtained from his lab using a progressive animal model of Parkinson’s disease.
His group has shown that weekly treatment with the neurotoxin, MPTP, for up to 4 weeks, results in a gradual loss of dopamine within the nigrostriatal pathway. He will discuss how this unique model may or may not correlate to the extent of motor function tests available and will discuss the sensitivity of gait analysis in describing mice with Parkinson’s disease. Dr. Meshul will also describe other studies in which deficits in nigrostriatal dopamine can be blocked or even reversed and whether certain measures of gait function can show corresponding improvement. Dr. Carol Milligan, Professor of Neurobiology & Anatomy at Wake Forest School of Medicine, will present on behavioral deficits that correlate with early pathology in the SOD1 mouse model of amyotrophic lateral sclerosis (ALS). As Dr. Milligan describes, one potential explanation for why preclinical studies in animal models have not translated positively to clinical trials may be insufficient understanding of when and where pathogenesis begins.
Characterization of these early events and correlation to human disease is essential, however, for insight into disease onset, discovery of presymptomatic diagnostic disease markers, and identification of novel therapeutic targets. Dr. Milligan will highlight early pathological changes identified in her lab and, importantly, analysis of mouse movement that has revealed deficits corresponding to early pathology. She will also highlight that careful characterization of disease models is critical to the design of scientifically sound preclinical studies.
Professor, Neurobiology & Anatomy
President and CSO, Mouse Specifics Inc.
Below is a comparison of the protocols for recording electrocardiograms in awake mice. On the left is a partial description of the steps involved if using telemetric implants. On the right are the steps involved if using the ECGenie. Read More
End the debate and speculation about whether voluntary walking is better for your research than treadmill walking…
6. Neuromusculoskeletal modelling and the gain transition of a quadruped according to its speed in rats
This poster details a neuromusculoskeletal model of rat hind limbs during walking and trotting. Toeda and colleagues from Tokyo developed a musculoskeletal model of the fore- and hind limbs of the rat based on empirical anatomical data. To model the muscles, they focused on six prime muscle for the forelimbs, and seven muscles for hind limbs. respectively.
They present a neural system model invoking limb movement control, according to muscle synergy to account for coordinated structure in muscle activities, and postural feedback control, based on shoulder height, hip height and horizontal center of mass velocity. They present simulations of walking and trotting gait, and impose defects of the postural feedback system (by lesions to the cerebellum) to induce unstable gaits and tripping.
3. Because we’re all about that mouse, ‘bout that mouse, and gerbil….. ♫ ‘
There is a growing awareness of the link between compromised heart function and nervous system abnormalities. This point is beautifully conveyed in a poster presented by Dr. Anand Pandey and colleagues this coming Sunday at SfN. We are particularly excited to see how treadmill locomotion in rats is affected after cardiac arrest.
The heart is a powerful organ, sending blood through thousands of miles of vessels to fuel the body. This intricate system works continuously, rhythmically ~100,000 times per day, to provide us humans with oxygen and nutrients while cleansing our systems of harmful waste. Each cycle is activated by an electrical impulse. Read More